HIV-1感染者肠道菌群有变化

Title：
Alterations in the Fecal Microbiota of Patients with HIV-1 Infection: An Observational Study in A Chinese Population

DOI：
10.1038/srep30673

Abstract：
The available evidence suggests that alterations in gut microbiota may be tightly linked to the increase in microbial translocation and systemic inflammation in patients with human immunodeficiency virus 1 (HIV-1) infection. We profiled the fecal microbiota as a proxy of gut microbiota by parallel barcoded 454-pyrosequencing in 67 HIV-1-infected patients (32 receiving highly active antiretroviral therapy [HAART] and 35 HAART naïve) and 16 healthy controls from a Chinese population. We showed that α-diversity indices did not differ significantly between the healthy control and HIV-1-infected patients. The ratio of Firmicutes/Bacteroidetes increased significantly in HIV-1-infected patients. Several key bacterial phylotypes, including Prevotella, were prevalent in HIV-1-infected patients; whereas Phascolarctobacterium, Clostridium XIVb, Dialister and Megamonas were significantly correlated with systemic inflammatory cytokines. After short-term, effective HAART, the viral loads of HIV-1 were reduced; however, the diversity and composition of the fecal microbiota were not completely restored. and the dysbiosis remained among HIV-1-infected subjects undergoing HAART. Our detailed analysis demonstrated that dysbiosis of fecal microbiota might play an active role in HIV-1 infection. Thus, new insights may be provided into therapeutics that target the microbiota to attenuate the progression of HIV disease and to reduce the risk of gut-linked disease in HIV-1-infected patients.

All Authors：
Zongxin Ling,Changzhong Jin,Tiansheng Xie,Yiwen Cheng,Lanjuan Li,Nanping Wu

First Authors：
Zongxin Ling

Correspondence：
Lanjuan Li,Nanping Wu

内容要点：

1、67名HIV-1感染者，其中32人接受高效抗逆转录病毒治疗(HAART)，另有16名健康人作对照，对粪菌进行测序；

2、 对比健康人对照和HIV感染者，粪菌的α-多样性指数无显著不同；

3、 HIV感染者中：F/B比值显著增加，包括普氏菌在内的几个关键属占优，而考拉杆菌属、梭菌属XIVb、小类杆菌属、巨单胞菌属与全身性炎症细胞因子显著相关；

4、 经过短时有效的HAART，HIV-1的病毒载量降低，然而粪菌的多样性和组成并没有完全恢复，失衡也依然存在。