昼夜节律与肠道微生物的关系

Title：
Circadian Rhythm and the Gut Microbiome

DOI：
10.1016/bs.irn.2016.07.002

Abstract：
Circadian rhythms are 24-h patterns regulating behavior, organs, and cells in living organisms. These rhythms align biological functions with regular and predictable environmental patterns to optimize function and health. Disruption of these rhythms can be detrimental resulting in metabolic syndrome, cancer, or cardiovascular disease, just to name a few. It is now becoming clear that the intestinal microbiome is also regulated by circadian rhythms via intrinsic circadian clocks as well as via the host organism. Microbiota rhythms are regulated by diet and time of feeding which can alter both microbial community structure and metabolic activity which can significantly impact host immune and metabolic function. In this review, we will cover how host circadian rhythms are generated and maintained, how host circadian rhythms can be disrupted, as well as the consequences of circadian rhythm disruption. We will further highlight the newly emerging literature indicating the importance of circadian rhythms of the intestinal microbiota.

All Authors：
RM Voigt,A Keshavarzian

First Authors：
RM Voigt

Correspondence：
A Keshavarzian

内容要点：

1、昼夜节律使生物学功能与规律可预测的环境节律相适应，以优化生物体的功能及健康；

2、扰乱昼夜节律可能造成代谢综合征、癌症或心血管疾病等的发生；

3、肠道菌群同样受到宿主器官及内在生物钟的调节；

4、肠道菌群的节律还受到饮食及进食时间的调节；

5、本综述介绍了宿主昼夜节律如何产生并维持及如何被扰乱，包括昼夜节律被扰乱的后果，并强调了肠道菌群的生理节律的重要性。