肠道菌群如何与其他器官交流？

Title：

How gut microbes talk to organs: The role of endocrine and nervous routes

DOI：

10.1016/j.molmet.2016.05.011

Abstract：

Background Changes in gut microbiota composition and activity have been associated with different metabolic disorders, including obesity, diabetes, and cardiometabolic disorders. Recent evidence suggests that different organs are directly under the influence of bacterial metabolites that may directly or indirectly regulate physiological and pathological processes. Scope of review We reviewed seminal as well as recent papers showing that gut microbes influence energy, glucose and lipid homeostasis by controlling different metabolic routes such as endocrine, enteric and central nervous system. These dialogues are discussed in the context of obesity and diabetes but also for brain pathologies and neurodegenerative disorders. Major conclusions The recent advances in gut microbiota investigation as well as the discovery of specific metabolites interacting with host cells has led to the identification of novel inter-organ communication during metabolic disturbances. This suggests that gut microbes may be viewed as “novel” future therapeutic partners.

All Authors：

Patrice D Cani,Claude Knauf

First Authors：

Patrice D Cani

Correspondence：

Patrice D Cani,Claude Knauf

内容要点：

1、近期的研究证据表明，不同器官都会受到细菌代谢产物的直接影响，从而可能直接或间接调节生理和病理学进程；

2、肠道菌群通过控制内分泌、肠内和中枢神经系统的不同代谢路径，以影响能量、葡萄糖和脂类平衡；

3、这些对话不仅仅在肥胖和糖尿病中存在，也在大脑和神经退行性疾病中存在；

4、靶向肠道微生物，在未来或许可作为一种“新型的”治疗神经系统疾病的方法。