人体皮肤菌群构成

Title：

Microbiome in healthy skin, update for dermatologists

DOI：

10.1111/jdv.13965

Abstract：

The skin is a complex barrier organ made of a symbiotic relationship between microbial communities and host tissue via complex signals provided by the innate and the adaptive immune systems. It is constantly exposed to various endogenous and exogenous factors which impact this balanced system potentially leading to inflammatory skin conditions comprising infections, allergies or autoimmune diseases. Unlike the gut and stool microbiome which has been studied and described for many years, investigations on the skin or scalp microbiome only started recently. Researchers in microbiology and dermatology started using modern methods such as pyrosequencing assays of bacterial 16S rRNA genes to identify and characterize the different microorganisms present on the skin, to evaluate the bacterial diversity and their relative abundance and to understand how microbial diversity may contribute to skin health and dermatological conditions. This article aims to provide an overview on the knowledge about the skin microbiota, the microbiome and their importance in dermatology.

All Authors：

B Dreno, E Araviiskaia,Berardesca,Gontijo,Sanchez Viera,LF Xiang,R Martin,T Biebe

First Authors：

B Dreno

Correspondence：

B Dreno

内容要点：

1、皮肤是一个复杂的屏障器官，由微生物菌群和宿主组织共生构成，由先天和适应性免疫提供相互作用信号；2、经常暴露于各种影响皮肤稳态的内外因素下可能导致炎性皮肤病如感染、过敏或自身免疫性疾病；

3、微生物学和皮肤病的研究者使用现代方法分析细菌16S rRNA基因来识别描述皮肤上的不同微生物，评估细菌多样性何相对丰度，了解微生物多样性怎样保持皮肤健康和皮肤病的状态；

4、本文旨在概述皮肤微生物群，皮肤病的微生物及其重要性的相关知识。