从饮食干预获得增加Akkermansia muciniphila这一新兴益生菌

Title：
Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies

DOI：
10.1016/j.jff.2017.03.045

Abstract：
Akkermansia muciniphila is a mucin-degrading bacterium commonly found in human gut. A. muciniphila has been inversely associated with obesity, diabetes, inflammation, and metabolic disorders. Due to its highly promising probiotic activities against obesity and diabetes, A. muciniphila has drawn intensive interest for research and development in recent years. A number of human and animal studies have shown that the abundance of A. muciniphila in the gut can be enhanced through dietary interventions. The present review focuses on evidence-based dietary strategies of improving A. muciniphila abundance in the gut by critically appraising up-to-date available human and animal intervention studies on A. muciniphila growth and their impact on risk factors of obesity and diabetes. Their potential mechanisms in promoting A. muciniphila are also discussed along with the discussions of mechanism of action for A. muciniphila to exert probiotic functions.

All Authors：
Kequan Zhou

First Authors：
Kequan Zhou

Correspondence：
Kequan Zhou

内容要点：

1、Akkermansia muciniphila（以下暂称Akk菌）是人体肠道中一种可降解黏蛋白的细菌，它与肥胖、糖尿病、炎症和代谢紊乱呈负相关；

2、它发挥益生作用的机制可能是可以调节肠道内黏液厚度和维持肠道屏障完整性；

3、增加Akk菌丰度的方法包括：摄入双歧杆菌、低聚果糖、短链碳水化合物（FODMAP）、二甲双胍、大黄提取物或特定抗生素

4、而摄入膳食类多酚和热量限制（CR）是否有效存在争议；⑤ 高脂饮食和大量饮酒则会减少肠道内Akk菌的丰度。