基于氨基酸的配方奶粉对非IgE介导的过敏婴儿肠道菌群的改善
Title：
A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants
Abstract：
Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow’s milk allergy (CMA).This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age matched healthy breastfed infants were used as reference (HBR) for primary outcomes. CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.Thirty-five (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, median percentage of bifidobacteria was higher in test group vs control group (35.4 vs. 9.7%, respectively P<0.001), whereas ER/CC was lower (9.5 vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55 and 6.5%, respectively.AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.
All Authors：
David C A Candy, Marleen T J Van Ampting, Manon M Oude Nijhuis, Harm Wopereis, Assad M Butt, Diego G Peroni, Yvan Vandenplas, Adam T Fox, Neil Shah, Christina E West, Johan Garssen, Lucien F Harthoorn, Jan Knol, Louise J Michaelis
First Authors：
David C A Candy
Correspondence：
Marleen T J Van Ampting
内容要点：
在一项多中心随机双盲对照试验中，选取71名牛奶过敏（非IgE介导）的婴儿。 婴儿随机分为2组，分析添加了合生元（低聚果糖+短双歧杆菌M-16V）的基于氨基酸的配方奶粉（AAF）的效果。干预8周后，相比于对照组，实验组粪便中的双歧杆菌比例的中位数显著升高，直肠真杆菌/拟球梭菌（ER/CC）比例显著降低。母乳喂养的健康婴儿，双歧杆菌比例更高，ER/CC比值更低，提示添加了合生元的AAF可改善牛奶过敏婴儿的肠道菌群。