高盐饮食损伤肠道菌群，从而促进高血压的发生
Title：
Salt-responsive gut commensal modulates TH17 axis and disease
Abstract：
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating TH17 cells. In line with these findings, a moderate high-salt challenge in a pilot study in humans reduced intestinal survival of Lactobacillus spp., increased TH17 cells and increased blood pressure. Our results connect high salt intake to the gut–immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions.
All Authors：
Nicola Wilck , Mariana G Matus , Sean M Kearney , Scott W Olesen , Kristoffer Forslund , Hendrik Bartolomaeus , Stefanie Haase , Anja Mähler , András Balogh , Lajos Markó , Olga Vvedenskaya , Friedrich H Kleiner , Dmitry Tsvetkov , Lars Klug , Paul I Costea , Shinichi Sunagawa , Lisa Maier , Natalia Rakova , Valentin Schatz , Patrick Neubert , Christian Frätzer , Alexander Krannich , Maik Gollasch , Diana A Grohme , Beatriz F Côrte-Real , Roman G Gerlach , Marijana Basic , Athanasios Typas , Chuan Wu , Jens M Titze , Jonathan Jantsch , Michael Boschmann , Ralf Dechend , Markus Kleinewietfeld , Stefan Kempa , Peer Bork , Ralf A Linker , Eric J Alm, Dominik N Müller
First Authors：
Nicola Wilck
Correspondence：
Eric J Alm, Dominik N Müller
内容要点：
高盐导致高血压和心血管疾病，其诱导TH17并促进自身免疫和血压升高，而TH17的诱导还依赖于肠道菌群。 高盐损伤小鼠肠道菌群，特别是减少鼠乳杆菌。给小鼠喂食鼠乳杆菌，则能调节TH17，以阻止因盐诱发的实验性自身免疫性脑脊髓炎和盐敏感性高血压恶化。与动物实验一致的是，在先导性人体研究中发现，中度高盐减少肠道乳杆菌属，增加TH17数量并促进血压升高。 高盐摄入正式与肠道-免疫轴建立相关，肠道菌群或是应对高血压的有效靶点。