肠道菌群代谢植物雌激素，与心血管疾病风险因素有一定的关联性

Title：
Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

DOI：
10.1002/mnfr.201500900

Abstract：
Recent evidence supports that the gut microbial community, independently and/or interactively with dietary intake, is a target for reducing cardiovascular disease risk through its effects on cardiometabolic risk factors. Dietary phytoestrogens may be a source for interactive effects. Phytoestrogens, such as isoflavones, lignans, and flavonoids, are compounds found in plants that have estrogenic or antiestrogenic activities, as well as antioxidant, antiproliferative, or apoptotic actions. Given these physiological activities, phytoestrogens may have a role in cardiometabolic health. Some phytoestrogens consumed in the diet undergo biotransformation through gut bacterial metabolism to other compounds that may exhibit similar or different physiological activity than the parent compound. There is interindividual variability in the capability to metabolize phytoestrogens to their metabolites, and there is a resulting phenotype that can be evaluated based on urinary metabolite excretion. Evidence suggests that phytoestrogen metabolites and/or phenotypes are associated with cardiometabolic risk factors, such as blood pressure, abdominal obesity, and serum lipids, triglycerides, glucose, and inflammatory markers. The objective of this review was to provide an overview of the observed associations between gut microbial phytoestrogen metabolites and metabolite phenotypes with cardiometabolic risk factors, with focus on the more extensively studied isoflavone metabolites.

All Authors：
Cara L Frankenfeld

First Authors：
Cara L Frankenfeld

Correspondence：
Cara L Frankenfeld

摘要：

       肠道菌群与膳食摄入量相关，是降低心血管疾病风险的靶标，另外植物雌激素是一类具有多种生理功能的化合物；我们日常生活中摄入的植物雌激素可通过肠道菌群代谢转化成其他化合物，进而产生相似或不同的生理作用，由于植物雌激素代谢物存在着个体代谢差异，进而导致了尿液或排泄物的表型差异； 证据表明植物雌激素代谢物或表型与代谢性疾病的危险因素（如血压，血脂等）相关；文章中介绍了肠道菌群代谢植物雌激素的产物和代谢表型与代谢性疾病风险因素之间关联性。