人一生中的鼻腔菌群的变化


Title:
Bacterial microbiota of the nasal passages across the span of human life

DOI:
10.1016/j.mib.2017.10.023

Abstract:
The human nasal passages host major human pathogens. Recent research suggests that the microbial communities inhabiting the epithelial surfaces of the nasal passages are a key factor in maintaining a healthy microenvironment by affecting both resistance to pathogens and immunological responses. The nasal bacterial microbiota shows distinct changes over the span of human life and disruption by environmental factors might be associated with both short- and long-term health consequences, such as susceptibility to viral and bacterial infections and disturbances of the immunological balance. Because infants and older adults experience a high burden of morbidity and mortality from respiratory tract infections, we review recent data on the bacterial nasal microbiota composition in health and acute respiratory infection in these age groups.

All Authors:
Lindsey Bomar,Silvio D Brugger,Katherine P Lemon

First Authors:
Lindsey Bomar

Correspondence:
Katherine P Lemon

内容要点:

鼻腔菌群通过抵抗病原菌、提高免疫应答以维护微环境健康,在一生中随环境而改变,可能会导致短期或长期健康问题。婴儿阶段,人类鼻病毒(HRV)和呼吸道合胞病毒(RSV)可能导致急性呼吸道感染,肺炎链球菌、流感嗜血杆菌和金黄色葡萄球菌会使鼻腔菌多样性降低。青春期前儿童鼻腔菌群中变形菌门和壁厚菌门较多,而成人放线菌门占比较多,身体衰老也可能影响鼻腔菌群。鼻腔菌群具有治疗和预防呼吸道感染、调节呼吸道疾病的潜在作用。

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