膳食纤维富集肠道菌群可改善II型糖尿病
Title：
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Abstract：
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, deficiency of which is associated with type 2 diabetes mellitus (T2DM). Here, we show by a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, that a selective group of SCFA-producing strains was promoted by dietary fibers while most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers restored to greater diversity and higher abundance, participants had better improvement in HbA1c partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.
All Authors：
Liping Zhao1,3†*, Feng Zhang1†, Xiaoying Ding2†, Guojun Wu1†, Yan Y Lam3†, Xuejiao Wang2, Huaqing Fu1, Xinhe Xue1, Chunhua Lu4, Jilin Ma4, Lihua Yu4, Chengmei Xu4, Zhongying Ren4, Ying Xu5, Songmei Xu5, Hongli Shen5, Xiuli Zhu5, Yu Shi6, Qingyun Shen6, Weiping Dong2, Rui Liu1, Yunxia Ling2, Yue Zeng7, Xingpeng Wang7, Qianpeng Zhang1, Jing Wang1, Linghua Wang1, Yanqiu Wu1, Benhua Zeng8, Hong Wei8, Menghui Zhang1, Yongde Peng2*, Chenhong Zhang1*
First Authors：
Liping Zhao1,3†*, Feng Zhang1†, Xiaoying Ding2†, Guojun Wu1†, Yan Y Lam3†,
Correspondence：
Liping Zhao1,3†*, Yongde Peng2*, Chenhong Zhang1*
摘要：
将2型糖尿病患者随机分成两组，均采用阿卡波糖治疗，其中U组（16例）为常规治疗组，W组（27例）接受同等热量的高膳食纤维营养干预；结果显示W组的糖化血红蛋白等指标改善得更快更好，该临床效果可经粪菌移植在小鼠中重现； 发现在治疗过程中患者肠道菌群结构改变，高膳食纤维富集了由15株乙酸和丁酸产生菌组成的功能群，抑制了吲哚和硫化氢产生菌； 这组菌尤其增加丁酸的生成量，促进GLP-1和PYY分泌并改善血糖，其丰度和多样性与临床治疗效果呈显著相关。