抑制免疫细胞活化可治疗高血压

Title：
Restraining immunity could lower high blood pressure

DOI：
10.1126/science.359.6379.966

Abstract：
The immune system is an underappreciated culprit in hypertension. Numerous studies suggest that immune cells increase blood pressure in rodents, and some evidence suggests they do the same in people. Activated immune cells harm the kidneys and the lining of the blood vessels, causing changes that increase blood pressure. In the kidneys, for instance, the cells promote the retention of sodium, which boosts blood pressure. Researchers have identified a compound, 2-HOBA, that curbs immune cells' effects on blood pressure in mice with hypertension. 2-HOBA blocks the effects of oxidized lipids that can damage proteins and activate immune cells. Researchers hope to begin a clinical trial of the compound in people.

All Authors：
Mitch Leslie

First Authors：
Mitch Leslie

Correspondence：
Mitch Leslie

摘要：

      免疫系统在高血压中起到关键作用，有些研究提示免疫细胞可导致啮齿动物，甚至是人体的血压升高：原因是 活化的免疫细胞可损伤肾脏及血管内壁，从而造成血压的升高； 比如在肾脏中，免疫细胞促进钠离子的滞留，从而起到生压作用；而调节性T细胞可减少小鼠的血管损伤并降低血压；一种可抑制免疫细胞活化的化合物——2-HOBA，可阻断氧化脂质对蛋白的损伤及对免疫细胞的活化，从而抑制小鼠体内因免疫细胞造成的高血压。